Antisense Drug Delivery to the Brain Targeting: Initial Applications in Anti-HIV Delivery Vehicle for Effective Brain for the Transferrin Receptor Serves as a An Antibody-Avidin Fusion Protein Specific
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An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.
In the present study a novel Ab-avidin fusion protein has been constructed to deliver biotinylated compounds across the blood brain barrier. This fusion molecule consists of an Ab specific for the transferrin receptor genetically fused to avidin. The Ab-avidin fusion protein (anti-TfR IgG3-CH3-Av) expressed in murine myeloma cells was correctly assembled and secreted and showed both Ab- and avi...
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تاریخ انتشار 1999